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THE PEPTIDE PRESCRIPTION Inaugural Column by Macrene Alexiades, MD, PhD, for Healio Dermatology

Dr. Alexiades' inaugural column for Healio Dermatology examines one of the most talked-about — and most misunderstood — categories in modern skincare and medicine: peptides. Drawing on her background as a Harvard-trained physician-scientist and her ongoing clinical research, the column separates rigorous evidence from marketing claims across four domains: topical peptides with genuine clinical support, systemic peptides including GLP-1 therapies, the emerging longevity scienc

Macrene Alexiades

Jul 291 min read

Q&A: How energy-based devices can improve GLP-1-related skin sagging

PUBLISHED REPORT in HEALIO Macrene Alexiades, MD, PhD, FAAD Key takeaways: Rapid weight loss with GLP-1 receptor agonists is associated with collagen loss and structural changes to the skin. Early intervention with energy-based devices and cosmetic fillers can counter these effects.manufacturing processes. As GLP-1 receptor agonists drive unprecedented weight loss, patients are achieving goal weights but face new aesthetic concerns. Skin laxity related to the use of GLP-1 rec

Macrene Alexiades

May 315 min read

Dr Macrene Alexiades Published Article in Healio, entitled "FDA issues complete response letter for trenibotulinumtoxinE"

PUBLISHED REPORT in HEALIO Macrene Alexiades, MD, PhD, FAAD Key takeaways: TrenibotulinumtoxinE is a fast-acting, short-term neurotoxin for treatment of glabellar lines. The FDA’s complete response letter to AbbVie requests more information about the toxin’s manufacturing processes. The complete response letter from the FDA to AbbVie regarding trenibotulinumtoxinE is best understood not as a scientific setback, but as a reminder of where the regulatory bar sits for complex bi

Macrene Alexiades

Apr 262 min read

What Does a Harvard PhD in Genetics Actually Bring to Dermatology?

When I look at your skin, I am not only seeing a clinical presentation. I am seeing the downstream expression of cellular and molecular processes that I spent years studying at Harvard — and that changes everything about how I treat it. Dr. Macrene Alexiades MD PhD on what a doctorate in Genetics actually brings to dermatology.

Macrene Alexiades

Mar 293 min read

Introduction to Dr Alexiades Podcast

In this introduction, I provide an overview of the structure and function of the skin, the underpinnings of skin health and skin aging, and the elements of skincare that work to restore and rejuvenate skin.

Macrene Alexiades

Feb 281 min read

Episode 6: Exosomes: Science vs. Hype in Skincare

In this episode of Skin Skin Longevity, Dr. Macrene Alexiades delves into the world of exosomes, a hot topic in dermatology and aesthetics. She begins by explaining what exosomes are—tiny extracellular vesicles that serve as biological messengers, carrying proteins, lipids, and genetic material between cells. Dr. Alexiades emphasizes the importance of understanding the scientific basis behind exosomes, separating fact from marketing hype, and discusses their potential applica

Macrene Alexiades

Feb 281 min read

Episode 5: Sun Damage to Skin Cancer: The Alexiades Scale and Photodynamic Therapy

Join Dr. Macrene Alexiades, a trailblazer in dermatology, as she explores the complexities of sun damage and photoaging. This episode delves into the Alexiades Classification Scale, a groundbreaking tool that differentiates between intrinsic and extrinsic aging, offering a personalized approach to skin care. Dr. Alexiades also highlights the role of photodynamic therapy in treating precancerous lesions and enhancing skin health. Discover how cutting-edge research and therapie

Macrene Alexiades

Feb 282 min read

Episode 4: Peptides in Skincare

As dermatologist and scientist, I provide education on skin and its aging process. I emphasize the importance of understanding the skin as an organ and the need to protect, restore, and maintain its health. In this episode, I delve into the world of peptides in skincare, explaining their structure, function, and importance in promoting skin health and longevity. I categorize peptides based on their roles, including dermal regulators, pigment regulators, and neuropeptides, and

Macrene Alexiades

Feb 282 min read

Episode 3: DNA Repair in Skincare

In this episode, Dr. Macrene Alexiades discusses the importance of DNA repair in preventing skin damage and aging. She explains how DNA damage occurs due to free radicals and various environmental factors, such as UV radiation and pollution. Dr. Alexiades emphasizes the role of DNA replication and the need for accurate base pairing. She explores different types of DNA repair mechanisms, including direct reversal, excision repair, and post-replication repair. The podcast also

Macrene Alexiades

Feb 282 min read

Episode 2: Free Radicals & Antioxidants

In this podcast episode, Dr. Macrene Alexiades discusses the damage that occurs to the skin due to free radicals and the importance of antioxidants in protecting and repairing the skin. Free radicals are highly reactive molecules that can cause damage to proteins, lipids, and DNA in the skin. This damage can lead to skin aging and potentially skin cancer. Antioxidants work by neutralizing free radicals and preventing them from causing further damage. Dr. Alexiades emphasizes

Macrene Alexiades

Feb 281 min read

Episode 1: Holistic Approach to Skin Health

In this podcast episode, Dr. Macrene Alexiades MD PhD Dermatologist & Geneticist discusses the damage that occurs to the skin due to free radicals and the importance of antioxidants in protecting and repairing the skin. Free radicals are highly reactive molecules that can cause damage to proteins, lipids, and DNA in the skin. This damage can lead to skin aging and potentially skin cancer. Antioxidants work by neutralizing free radicals and preventing them from causing further

Macrene Alexiades

Feb 281 min read

Dr. Macrene Alexiades MD PhD Podcast: Skin Longevity & Skin Health

Dr. Macrene Alexiades, MD PhD, dermatologist and scientist, provides education on skin and its aging process. She emphasizes the importance of understanding the skin as an organ and the need to protect, restore, and maintain its health. Dr. Macrene discusses the structure of the skin, including the different types of cells and layers, and explains how UV exposure can cause damage to the skin. She highlights the role of DNA repair and antioxidants in preventing and repairing skin damage. Dr. Macrene also delves into the connection between skin aging and skin cancer, and the importance of a holistic approach to skin health.